![]() ![]() Phone: 49.228.287.14799 Email: Or to: Hubert Schrezenmeier, Institute of Transfusion Medicine, University of Ulm and Institute of Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service and University Hospital Ulm, Helmholtzstrasse 10, 89081 Ulm, Germany. ![]() paroxysmal nocturnal hemoglobinuria, leukemia, immunologic disorders. 1 2 3 The variant leads to a lack of glycosylphosphatidylinositol (GPI)-anchored proteins on the surface of blood cells, which in turn leads to an inappropriate immune response to, and hemolysis of. Krawitz, Institute for Genomic Statistics and Bioinformatics, Rheinische Friedrich-Wilhelms-Universität, Sigmund-Freud Street 25, 53127 Bonn, Germany. Finally, there were no data on smoking habits or other potential confounding. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, potentially life-threatening acquired stem cell disorder caused by a variant in the PIGA gene. HS, PMK, and TK contributed equally to this paper.Īddress correspondence to: Taroh Kinoshita, Yabumoto Department of Intractable Disease Research, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. Phone: 49.731.150.550 Email: note: BH, YM, and MO contributed equally to this paper. Krawitz, Institute for Genomic Statistics and Bioinformatics, Rheinische Friedrich-Wilhelms-Universität, Sigmund-Freud Street 25, 53127 Bonn, Germany. 1Institute of Transfusion Medicine, University of Ulm, Ulm, Germany.ĢInstitute of Clinical Transfusion Medicine and Immunogenetics, German Red Cross Blood Transfusion Service and University Hospital Ulm, Ulm, Germany.ģResearch Institute for Microbial Diseases andĤWPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.ĥDepartment of Hematology and Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan.ĦInstitute for Genomic Statistics and Bioinformatics, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.ħDepartment of Neurology, Kobe City Medical Center General Hospital, Kobe, Japan.ĨDepartment of Tumor Immunology, Osaka International Cancer Institute, Osaka, Japan.ĩDepartment of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.ġ0Institute for Human Genetics,Medical Faculty, RWTH University Aachen, Aachen, Germany.ġ1Department of Medical Genetics, Charite Hospital, University of Berlin, Berlin, Germany.ġ2MLL Muenchner Leukaemielabor GmbH, Munich, Germany.Īddress correspondence to: Taroh Kinoshita, Yabumoto Department of Intractable Disease Research, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. ![]()
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